Nomenclature of the desmosomal cadherins
نویسندگان
چکیده
* Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom; ~New York University Medical Center, School of Medicine, New York University, New York 10016; §Institut fiir Zellund Tumorbiologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Postfach 10 19 49, D-6900 Heidelberg 1, Germany; II Department of Biological Sciences, Stopford Building, University of Manchester, Manchester M13 9PT, United Kingdom; I Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611-3008; ~Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; and §§Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544-1014
منابع مشابه
Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains.
Two cell-cell junctions, the adherens junction and the desmosome, are prominent in epithelial cells. These junctions are composed of transmembrane cadherins which interact with cytoplasmic proteins that serve to link the cadherin to the cytoskeleton. One component of both adherens junctions and desmosomes is plakoglobin. In the adherens junction plakoglobin interacts with both the classical cad...
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Desmosomes are unique intercellular junctions in that they invariably contain two types of transmembrane cadherin molecule, desmocollins and desmogleins. In addition they possess a distinct cytoplasmic plaque structure containing a few major proteins including desmoplakins and the armadillo family member plakoglobin. Desmosomal cadherins are putative cell-cell adhesion molecules and we have tes...
متن کاملDesmosomal Cadherins in Basal Cell Carcinomas
During recent years desmosomal research has developed into a biomedical field focused on the role of desmosomal components in tissue development and homeostasis. Investigators’ area of interest involves the influence of cell adhesion defects and abnormal cell signaling on cancer invasion and metastasis. Some data indicated that there is greater cell proliferation activity in basal cell carcinom...
متن کاملThe binding of plakoglobin to desmosomal cadherins: patterns of binding sites and topogenic potential
Plakoglobin is the only protein that occurs in the cytoplasmic plaques of all known adhering junctions and has been shown to be crucially involved in the formation and maintenance of desmosomes anchoring intermediate-sized filaments (IFs) by its interaction with the desmosomal cadherins, desmoglein (Dsg), and desmocollin (Dsc). This topogenic importance of plakoglobin is now directly shown in l...
متن کاملDesmosomal adhesion inhibits invasive behavior.
Recent studies of human disease and transgenic animal experiments have clearly demonstrated the importance of desmosomes in normal tissue architecture. Furthermore, desmosomal components are down-regulated in certain types of carcinomas, suggesting a possible role for desmosomes in suppression of invasion and metastasis. However, there is no functional evidence to support such a hypothesis. To ...
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ورودعنوان ژورنال:
- The Journal of Cell Biology
دوره 121 شماره
صفحات -
تاریخ انتشار 1993